COLD AGGLUTININS. III. OBSERVATIONS ON CERTAIN SEROLOGICAL AND PHYSICAL FEATURES OF COLD AGGLUTININS IN CASES OF PRIMARY ATYPICAL PNEUMONIA AND OF HEMOLYTIC ANEMIA

Observations on Certain Sero- Logical and Physical Features of Cold Agglutinins in Cases of Primary Atypical Pneumonia and of Hemolytic Anemia

Some of the properties of cold agglutinins in certain human sera have been listed in a recent review (1). The knowledge concerning these properties is based on studies of the phenomenon by various methods in serum or plasma from isolated cases of a large variety of conditions. With respect to the cold agglutinins in cases of primary atypical pneumonia, limited studies of certain aspects were re...

Cold Agglutinins. Ii. Cold Isohemagglutinins in Primary Atypical Pneumonia of Unknown Etiology with a Note on the Occurrence of Hemolytic Anemia in These Cases.

In the preceding paper ( 1), there was presented a summary of the maximum titers of cold agglutinins found in 1069 cases of a variety of conditions, including the various infections of the respiratory tract that are commonly encountered in this vicinity. Significant titers (in dilutions greater than 20) were obtained only in cases of primary atypical pneumonia of unknown etiology,' and in a few...

Chronic hemolytic anemia due to cold agglutinins: the mechanism of resistance of red cells to C' hemolysis by cold agglutinins.

The red cells of patients with chronic hemolytic anemia due to cold agglutinins are agglutinated by antiglobulin serum in a nongamma reaction due to the coating of beta-globulins, C'4 and C'3. The red cells of such patients are abnormally resistant to C' hemolysis by cold agglutinin. Normal red cells can be made equally resistant to C' hemolysis by incubation with cold agglutinin and normal ser...

Cold Agglutinins. Vi. Agglutinins for an Indifferent Streptococcus in Primary Atypical Pneumonia and in Other Conditions and Their Relation to Cold Isohemagglutinins.

Platelet cold agglutinins.

A “cold” platelet agglutinin is described reacts only at temperatures below 34#{176}C. which is present in plasma and serum, It agglutinates homologous and autois greater than 100,000 in molecular logous platelets but appears to have no weight, appears to be a protein of the imeffect on in vivo platelet function. It is munoglobulin type, is adsorbed by plateseen in patients with systemic diseas...